Nobiletin

Description:

Nobiletin is a white powder,sources citrus peel and is an extract of Citrus aurantium.It can resist oxidation and inflammation, regulate oil secretion, and help different skin types maintain good condition. Nobiletin structure is stable and has good compatibility. It is a fat soluble component that does not interfere with product color. In terms of nobiletin solubility, it is easy to integrate into the formula. Because of its diverse effects, it is often used in face cream, essence anti-aging, sensitive muscle products and post sun repair, and can also meet the oil control and moisture requirements of different skin types.Nobiletin china factory ,Baisifu,is committed to high quality, providing COA, MSDS, TDS reports, and free samples. Our company is ISO 9001 & ISO 14001 certified and is cruelty-free.

Cas No.:478-01-3

Appearance: White Solid

Similar Name: 3′,4′,5,6,7,8 – hexamethoxyflavone

Solubility:Soluble in DMSO (up to 10 mg/ml)

Benefits:

In terms of nobiletin benefits, nobiletin powder has strong antioxidant capacity, like an efficient “free radical hunter”, which can effectively remove free radicals, prevent skin aging, and make the skin firm and elastic. Its excellent anti-inflammatory properties can alleviate inflammation caused by UV rays, pollution, etc., and carefully protect sensitive skin. In addition, nobiletin can accurately regulate oil, help oily skin control oil, and moisturize dry skin, suitable for all skin types.

Package:

Baisifu currently has wholesale prices for nobiletin for sale.This product is packaged in powder and comes in two sizes, 1kg/bag and 25kg/box.

General Information:

Mechanism of Action for Skincare Products

·  Antioxidant

Nobiletin searches for or scavenges ROS or reactive oxygen species, and shows lipid peroxidation. This helps to protect cellular membranes and collagen fibers from UV-induced and environmental oxidative stress levels. Furthermore, it modulates antioxidant-response pathways like Nrf2, enhancing the internal defense capacity of the skin.

· Anti-inflammatory

Nobiletin downregulates inflammatory middlemen like TNF-α, NF-кB, and COX-2. Via these pathways, it cuts down redness, swelling, sensitivity, and irritation caused by UV exposure, environmental stressors, and reactive skincare routines.

· Skin Brightening

It interferes with melanogenesis. This is done by overpowering the expression of MITF, or melanocyte-inducing transcription factor, and tyrosinase. It leads a reduction in dark spots, uneven tone, and hyperpigmentation. This makes it ideal for spot-correcting and brightening formulas.

Applications in Cosmetics Products

· Anti-aging

In anti-aging products, Nobiletin safeguards collagen fibers. Therefore, enhancing elasticity and reducing oxidative degradation. Some applications include firming lotions or creams, anti-aging serums, wrinkle-reducing lotions, eye-area revitalizing creams, etc.

· Antioxidant

Due to the strong free-radical scavenging capacity Nobiletin has, it is perfect for daily defense products or formulas. Some of its applications include environmental-protection creams, antioxidant serums, anti-pollution moisturizers, and protective mists.

· Anti-inflammatory

Perfect for soothing and sensitive-skin formulations. Some applications here include redness-relief creams, calming gels, soothing masks, and post-treatment recovery serums.

· Skin Brightening

Nobiletin in these products targets pigmentation as it enhances clarity. Some applications include dark-spot correctors, brightening serums, tone-evening cleansers, and pigmentation creams.

· Acne Treatment Products

In acne treatment products, Nobiletin cuts down inflammation as it inhibits acne-associated bacteria. Some major applications include spot-treatment gels, sebum-control moisturizers, acne serums, and clarifying toners.

· Antimicrobial

Nobiletin in antimicrobial products offers a wide spectrum of support against bacteria. This contributes to skin irritation and breakouts. Major applications here include anti-odor formulations, purifying cleansers, and microbial-control toners.

· Preservative

Nobiletin promotes microbial resistance when used along with preservation systems. Major applications include lotion gels, emulsions, and multifunctional cosmetic products with the aim of reduced preservative loads.

Formulation in Cosmetic Ingredients

· Solubility

Nobiletin is soluble in oils, propylene glycol, ethanol, and DMSO. However, it is poorly soluble in water. Furthermore, it is best to incorporate Nobiletin into oil phase of emulsions or even glycol- or alcohol based delivery systems.

· Purity Level

In cosmetic usage, the ideal purity of cosmetic-grade Nobiletin is ≤ 90%. However, for premium formulations, it is recommended to use between 95 to 98% purity. This helps in providing manufacturers the consistency in stability and performance required.

· Working pH

The ideal formulation pH range is between 5.0 – 7.5. This range works by preserving molecular stability and making sure the right level of efficacy in skin-brightening and anti-inflammatory actions is achieved.

· Recommended Concentration

How we Produce Cosmetic-Grade Nobiletin

At Baisifu, Nobiletin is extracted through a controlled citrus-peel purification process. This process uses advanced solvent-recovery systems and chromatography. Also, our cosmetic-grade Nobiletin undergoes various refinement stages, which leads to high purity, consistent polymethoxyflavone, and low residue level content. To offer you the best Nobiletin for your cosmetic productions, our production follows cGMP, ISO 22716, and international cosmetic-ingredient quality standards.

Safety Profile & Quality Compliance

Nobiletin is recognized worldwide to be safe for topical use within cosmetic concentrations. Also, it meets the regulatory standards and requirements in major markets like China, EU, and US when formulated under standard cosmetic methods or procedures. Baisifu offers a complete COA, heavy-metal analysis, purity testing, and microbial safety verification for every batch.

Why Choose Baisifu as your Nobiletin Supplier in China

At Baisifu, we offer high-purity, ISO 22716-certified cosmetic-grade Nobiletin that comes with strict traceability, quality control, and batch-to-batch consistency. We help manufacturers with the right level of formulation guidance, customizable specifications, technical documents, and all that is needed to meet different cosmetic product needs.

FAQs

1. What is the best source of Nobiletin?

Citrus peels, particularly oranges and tangerines. Baisifu utilizes controlled extraction to obtain high-purity cosmetic-grade Nobiletin.

2. Are there known side effects of Nobiletin in cosmetic products?

Although Nobiletin has no side effects, higher concentrations when used leads to irritation or mild dryness.

3. Which cosmetic ingredients are incompatible with Nobiletin?

Strong oxidizers, reactive metal ions, high-pH systems, and high-level AHAs/BHAs.

4. What is the recommended purity level of Nobiletin for cosmetic products formulations?

The recommended purity level is ≥90% purity, while premium formulas range from 95 to 98%.

5. Do you offer samples for Nobiletin testing?

Yes, we do.

6. is nobiletin stable in cosmetics?

Yes. Nobiletin is stable.