Monobenzone Powder

Monobenzone is a hydroquinone ester and 5-aminosalicylic acid-derivative. It acts as a depigmentation agent that is soluble in benzyl, alcohol, or diethyl ether and insoluble in water.

Its chemical formula is C₁₃H₁₂O₂ and 200.23 molecular weight.

Baisifu offers monobenzone for sale in different packaging sizes, such as 1kg/bag and 25kg/drum. We can also provide it in wide strength variations to meet your specific needs.

CAS Number: 103-16-2

Appearance: White Crystalline Powder

Other Name: 4-Benzyloxyphenol

Melting Point: 110-113°C

Monobenzone Powder

Monobenzone powder (C₁₃H₁₂O₂, MW 200.23 g/mol) is a high-purity crystalline raw material used widely in the pharmaceutical and cosmetic industries. At Baisifu, we provide consistent quality, full documentation, and secure packaging for your formulation requirements.

Common Uses

Monobenzone powder is not a universal raw material. It has specific applications in the pharmaceutical and cosmetic industries where performance, consistency and compliance dictate the success of products.

• Vitiligo treatment formulations: Used in dermatological products intended to reduce melanin in the skin areas around vitiligo spots to give a more uniform skin tone.
• Depigmenting creams: An active ingredient in topical formulations for controlled pharmaceutical and cosmetic research purposes.
• Medicated soaps: Incorporated into special cleansing bars aimed at specific depigmentation needs, in controlled frameworks of the product development.
• Pharma R&D: Supports studies of melanin reduction and depigmentation pathways in laboratory and pre-commercial research settings

At Baisifu, we put emphasis on producing high-purity and consistency. Therefore, you get ingredient with high efficacy during both the development and scale-up stages.

Recommended Usage

The usage levels for monobenzone powder depends on application and regional regulations. In pharmaceutical production, the formulations are often in accordance with pharmacopeia guidelines to meet the safety and efficacy standards. In cosmetic R&D environments, lower concentrations are used at early testing stages to monitor stability and interaction with other excipients.

Here are some recommended concentrations for monobenzone powder in different products:

• 5% to 10% – for products that will be used in sensitive areas such as face and kneck.
• 20% – in most cases, many manufacturers choose this a standard depigmentation therapy
• 30% to 40% – in situations where the users do not respond to formulations with 20%, then going for higher concentrations may help. These could be in areas like feet or hand that tend to have thicker skin. However, higher monobenzone concentrations may cause irritation.

With every monobenzone powder bulk supply, we deliver batch-specific technical documentation with definitive assay values, purity confirmation and regulatory support. Our technical professionals are there to help you find the best ranges that would meet your compliance needs and production objectives.

Compatibility with Cosmetic Ingredients

Compatibility is key when using monobenzone in a complex system. Our ingredients are tested and verified to integrate appropriately with common excipients and formulation bases.

Monobenzone powder is compatible with:

• Retinoids: It’s compatible if formulated carefully. Combining retinoids can improve the targeting of the pigments, but may increase irritation of the skin.
• Niacinamide (Vitamin B3): Highly compatible with monobenzone. Niacinamide’s anti-inflammatory properties can help to reduce the sensitivity of the skin, while overlapping pH ranges can help to avoid stability issues.
• Alpha Hydroxy Acids (AHAs): Compatible with the use of buffered formulations. AHAs, such as glycolic or lactic acid exfoliate the outer layer of skin, enhancing monobenzone penetration.
• Salicylic Acid: Compatible in oil-soluble formula designs. Needs careful pH balance (usually acid, around 3-4) and possible encapsulation to keep monobenzone from degradation
• Enzymatic Exfoliants (such as papain, bromelain): Often compatible within compatible pH ranges, although you must control water content and preservation systems to ensure stability.
• Hyaluronic Acid: It helps increase hydration and can enhance monobenzone delivery
• Glycerin: A stable humectant supporting hydration and penetration without affecting Monobenzone chemical stability that makes it a strong formulation partner.

This wide compatibility helps you reduce formulation work, reduce risk of reformulation, and accelerate your product development cycle.

Stability and Shelf Life

Monobenzone powder is generally stable if properly stored under a cool, dry condition away from direct light and moisture. Industry practice indicates proper storage helps to maintain purity and assay values. Packaging in sealed, protective containers is an additional way to help with stability during transport and warehousing.

Safety & Regulatory Compliance

Safety and compliance play a central role in our manufacturing process. Every batch of monobenzone powder is manufactured under Good Manufacturing Practice (GMP) standards and tested following stringent protocols.

We provide:

• Certificate of Analysis (COA) with purity and assay confirmation
• Material Safety Data Sheet (MSDS) for safe handling & regulatory submission
• Technical Data Sheet (TDS) specifying the product details

Our ingredients meet ISO quality standards and global safety standards. Heavy metals, microbial contamination and level of residues are well below regulatory limits. With our documentation, your compliance and regulatory documentation filing process is supported from development to commercialization.

Technical Specifications

Our monobenzone powder meets industry expectations for pharmaceutical and cosmetic raw materials.

• Purity: ≥ 99% (HPLC verified)
• Assay: Meets pharmacopeial standards
• Grades available: Pharmaceutical and cosmetic grade
• Chemical formula: C₁₃H₁₂O₂
• Molecular weight:23 g/mol
• CAS number: 103-16-2
• Appearance: White crystalline powder
• Melting point: 110–113 °C
• Heavy metals: ≤ 10 ppm
• Residue limits: ≤ 0.1%
• Loss on drying: ≤ 0.5%

Each shipment includes batch traceability and full documentation to meet your internal quality assurance systems.

Why Choose Baisifu  as your Monobenzone Powder Supplier in China

Baisifu delivers more than cosmetic ingredients raw material. Our monobenzone powder is produced under regulated standards with full documentation and delivered through a safe, efficient supply chain.

We offer flexible packaging, fast lead times and responsive customer support. By partnering with us, your business gets a reliable supplier dedicated to your success – request a free sample now.